Balanced 2(n) factorial designs when observations are spatially correlated

• Published in: Journal of biopharmaceutical statistics Vol. 19; no. 2; p. 332
• Main Authors: Sethuraman, Venkat, Raghavarao, Damaraju
• Format: Journal Article
• Language: English
• Published: England 2009
• Subjects: Algorithms; Biological Availability; Chemistry, Pharmaceutical; Data Interpretation, Statistical; Delayed-Action Preparations; Research Design

In this article we focus on the optimal factorial and fractional-factorial designs when observations within blocks are correlated. The topic was motivated by a problem when the pharmaceutical experimenter needed to develop a controlled release, once-daily tablet formulation. Typically, in order to c...