Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia

• Published in: Zhonghua nan ke xue Vol. 13; no. 4; p. 302
• Main Authors: Wang, Wei, Lu, Ning-xia, Xia, Yan-ai, Wang, Xin-ru, Zhang, Wei, Song, Ning-hong, Wei, Min, Su, Jian-tang
• Format: Journal Article
• Language: Chinese
• Published: China 01.04.2007
• Subjects: Adult; Azoospermia - genetics; Fas Ligand Protein - genetics; Genetic Predisposition to Disease; Genotype; Humans; Infertility, Male - genetics; Male; Middle Aged; Oligospermia - genetics; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length
• ISSN: 1009-3591

To study the distribution of FASL-844 polymorphism in southern Chinese males of Han nationality and examine the contribution of the polymorphism to susceptibility of idiopathic azoospermia and oligozoospermia. FASL-844 polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) in 184 infertile patients with idiopathic azoospermia or severe oligozoospermia 236 normal fertile male controls. Frequencies of FASL-844 CT and TT genotypes of the patients were significantly different from those of the controls (P = 0.024; P = 0.008). Males with FASL-844 TT genotype had an increased risk of idiopathic azoospermia or severe oligozoospermia compared with those with CC genotype (OR 2.76, 95% CI: 1.20-6.35), and even a higher risk when compared with those with CC and CT genotypes (OR 2.90, 95% CI: 1.28-6.58). FASL-844 polymorphism appears to be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among southern Chinese Han males.