Investigation of metabolite changes in the transition from pre-invasive to invasive cervical cancer measured using (1)H and (31)P magic angle spinning MRS of intact tissue

• Published in: NMR in biomedicine Vol. 22; no. 2; p. 191
• Main Authors: De Silva, Sonali S, Payne, Geoffrey S, Thomas, Valerie, Carter, Paul G, Ind, Thomas E J, deSouza, Nandita M
• Format: Journal Article
• Language: English
• Published: England 01.02.2009
• Subjects: Adult; Aged; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Female; Humans; Magnetic Resonance Spectroscopy - methods; Middle Aged; Neoplasm Invasiveness; Phosphorus Isotopes - analysis; Spin Labels; Uterine Cervical Neoplasms - metabolism; Uterine Cervical Neoplasms - pathology; Young Adult

The aim of this study was to determine the metabolic changes in the transition from pre-invasive to invasive cervical cancer using high-resolution magic angle spinning (HR-MAS) MRS. Biopsy specimens were obtained from women with histologically normal cervix (n = 5), cervical intraepithelial neoplasi...