RNA targeting by DNA binding drugs: structural, conformational and energetic aspects of the binding of quinacrine and DAPI to A-form and H(L)-form of poly(rC).poly(rG)

• Published in: Biochimica et biophysica acta Vol. 1770; no. 12; p. 1636
• Main Authors: Sinha, Rangana, Hossain, Maidul, Kumar, Gopinatha Suresh
• Format: Journal Article
• Language: English
• Published: Netherlands 01.12.2007
• Subjects: Binding Sites; Calorimetry - methods; DNA - metabolism; Indoles - metabolism; Indoles - pharmacology; Molecular Conformation; Poly C - metabolism; Poly G - metabolism; Quinacrine - metabolism; Quinacrine - pharmacology; RNA - drug effects; Spectrometry, Fluorescence; Spectrophotometry, Ultraviolet

A key step in the rational design of new RNA binding small molecules necessitates a complete elucidation of the molecular aspects of the binding of existing molecules to RNA structures. This work focuses towards the understanding of the interaction of a DNA intercalator, quinacrine and a minor groov...