Glutathione S-transferase M1, T1 genotypes and the risk of mountain sickness

• Published in: Zhonghua laodong weisheng zhiyebing zazhi Vol. 23; no. 3; p. 188
• Main Authors: Jiang, Chang-zheng, Li, Fang-ze, He, Mei-an, Sun, Shu-yong, Zhang, Shu-yu, Liao, Rong, Jia, Shu-ya, Zeng, Hua-song, Wu, Tang-chun
• Format: Journal Article
• Language: Chinese
• Published: China 01.06.2005
• Subjects: Acute Disease; Adult; Altitude Sickness - genetics; Case-Control Studies; Gene Frequency; Genetic Predisposition to Disease; Genotype; Glutathione Transferase - genetics; Humans; Male; Polymerase Chain Reaction; Polymorphism, Genetic; Risk Factors
• ISSN: 1001-9391

To explore the relationship between genetic polymorphisms of glutathione S-transferase (GST) M1, T1 and susceptibility to mountain sickness. Forty-three soldiers with acute mountain sickness and 80 healthy soldiers matching with sex/age and training under the same condition were divided into case group and control group. A multiple polymerase chain reaction method was used to detect GSTM1 and GSTT1 genes in genomic DNA isolated from peripheral blood cells from both cases and controls. The frequency of the GSTT1 positive genotype was significantly higher in cases (69.8%) than in controls (42.5%) (P = 0.004, OR = 3.12, 95% CI 1.42 approximately 6.86). The frequency of GSTM1 negative genotype was also higher in cases (72.1%) than in controls (52.5%) (P = 0.03, OR = 2.34, 95% CI 1.05 approximately 5.02). Persons with both GSTM1 and GSTT1 negative genotypes had 5-fold more risk than those with GSTT1 negative and GSTM1 positive genotypes in developing mountain sickness (OR = 5.04, 95% CI: 1.00 approximately 25.3).