Risk assessment of H5N1 human infection after an outbreak of avian influenza in water fowl

• Published in: Zhōnghuá yùfáng-yīxué zázhì Vol. 43; no. 1; p. 41
• Main Authors: Wang, Yu-lin, Liu, Yu-fei, Jiang, Li-yun, Liu, Yang, Yang, Zhi-cong, Hao, Ai-hua, Wu, Ye-jian, Li, Hai-lin, Li, Tie-gang, Wang, Ming
• Format: Journal Article
• Language: Chinese
• Published: China 01.01.2009
• Subjects: Animals; Antibodies, Viral - blood; China - epidemiology; Disease Outbreaks; Ducks; Humans; Influenza A Virus, H5N1 Subtype - genetics; Influenza A Virus, H5N1 Subtype - isolation & purification; Influenza A Virus, H5N1 Subtype - pathogenicity; Influenza in Birds - epidemiology; Influenza in Birds - transmission; Influenza, Human - epidemiology; Influenza, Human - transmission; Risk Assessment; China
• ISSN: 0253-9624

To evaluate the risk of human infection after the outbreak of avian influenza H5N1 in animals, and probe the possibility for virus transmission. By means of field epidemiological study, molecular epidemiology, serology and emergency surveillance, persons who had ever closely contacted with sick or dead poultry were observed. While, the RT-PCR and gene sequencing method were used to detect H5 nucleic acid from environmental swabs from 4 epidemic spots, and hemagglutination inhibition assay was also used to detect H5 antibody. Of 22 environmental swabs detected from 4 epidemic spots, one was positive for H5 nucleic acid, and the homogeneity was 95.9% as compared with H5N1 virus A/China/GD01/2006 (H5N1) found in Guangzhou in 2006 by gene sequence analysis. 62 environmental swabs from live poultry stalls of food markets near epidemic spot were detected negative. Six of 68 blood samples of contacts were positive for H9 antibody, and all were negative for H5 antibody. 68 throat swabs of contacts were detected negat