Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells

• Published in: British journal of haematology Vol. 126; no. 1; p. 81
• Main Authors: Karube, Kennosuke, Ohshima, Koichi, Tsuchiya, Takeshi, Yamaguchi, Takahiro, Kawano, Riko, Suzumiya, Junji, Utsunomiya, Atae, Harada, Mine, Kikuchi, Masahiro
• Format: Journal Article
• Language: English
• Published: England 01.07.2004
• Subjects: Adult; Aged; Biomarkers - analysis; CD4 Antigens; DNA-Binding Proteins - analysis; DNA-Binding Proteins - genetics; Female; Forkhead Transcription Factors; Humans; Immunohistochemistry - methods; Leukemia-Lymphoma, Adult T-Cell - immunology; Male; Middle Aged; Receptors, Interleukin-2; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes - immunology

Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix...