Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells

Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix...

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Published inBritish journal of haematology Vol. 126; no. 1; p. 81
Main Authors Karube, Kennosuke, Ohshima, Koichi, Tsuchiya, Takeshi, Yamaguchi, Takahiro, Kawano, Riko, Suzumiya, Junji, Utsunomiya, Atae, Harada, Mine, Kikuchi, Masahiro
Format Journal Article
LanguageEnglish
Published England 01.07.2004
Subjects
Adult
Aged
Biomarkers - analysis
CD4 Antigens
DNA-Binding Proteins - analysis
DNA-Binding Proteins - genetics
Female
Forkhead Transcription Factors
Humans
Immunohistochemistry - methods
Leukemia-Lymphoma, Adult T-Cell - immunology
Male
Middle Aged
Receptors, Interleukin-2
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocytes - immunology
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Summary:Adult T-cell leukaemia/lymphoma (ATLL) is an aggressive neoplastic disease that usually exhibits a CD4(+)CD25(+) phenotype. Regulatory T cells (Treg), which suppress T-cell effector function, are characterized by the co-expression of CD4 and CD25. We analysed the expression of forkhead/winged helix transcription factor (FoxP3), a specific marker that is important for the function of Treg, on ATLL cells from 17 patients (peripheral blood, n = 8; lymph node, n = 9). Real-time polymerase chain reaction and immunostaining detected FoxP3 expression in 10 ATLL cases, but was relatively down-regulated compared with Treg from normal subjects. These results indicate the association of ATLL and Treg.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0007-1048
DOI:10.1111/j.1365-2141.2004.04999.x