Protective effect of soybean saponins and major antioxidants against aflatoxin B1-induced mutagenicity and DNA-adduct formation

• Published in: Journal of medicinal food Vol. 5; no. 4; p. 235
• Main Authors: Jun, Hye-Seung, Kim, Sung-Eun, Sung, Mi-Kyung
• Format: Journal Article
• Language: English
• Published: United States 2002
• Subjects: Aflatoxin B1 - toxicity; alpha-Tocopherol; Anticarcinogenic Agents - pharmacology; Antioxidants - pharmacology; Ascorbic Acid; Butylated Hydroxytoluene; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - prevention & control; DNA Adducts - drug effects; Dose-Response Relationship, Drug; Glycine max - chemistry; Humans; Liver Neoplasms - pathology; Liver Neoplasms - prevention & control; Mutagenicity Tests; Mutagens - toxicity; Mutation - drug effects; Saponins - pharmacology; Treatment Outcome; Tumor Cells, Cultured

Saponins from various plant sources have been suggested as possible anticarcinogens. Major dietary sources of saponins include legumes such as soybeans. This study was performed to determine the effect of soybean saponins on aflatoxin B(1)(AFB(1))-induced mutagenicity and AFB(1)-DNA adduct formation...