Deficient expression of O(6)-methylguanine-DNA methyltransferase combined with mismatch-repair proteins hMLH1 and hMSH2 is related to poor prognosis in human biliary tract carcinoma

• Published in: Annals of surgical oncology Vol. 9; no. 4; pp. 371 - 379
• Main Authors: Kohya, Naohiko, Miyazaki, Kohji, Matsukura, Shiroh, Yakushiji, Hiroyuki, Kitajima, Yoshihiko, Kitahara, Kenji, Fukuhara, Masao, Nakabeppu, Yusaku, Sekiguchi, Mutsuo
• Format: Journal Article
• Language: English
• Published: United States 01.05.2002
• Subjects: Adaptor Proteins, Signal Transducing; Aged; Base Pair Mismatch - physiology; Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - metabolism; Bile Duct Neoplasms - pathology; Carcinoma - genetics; Carcinoma - metabolism; Carcinoma - pathology; Carrier Proteins; Chi-Square Distribution; DNA Repair - physiology; DNA-Binding Proteins; Female; Gallbladder Neoplasms - genetics; Gallbladder Neoplasms - metabolism; Gallbladder Neoplasms - pathology; Humans; Immunoenzyme Techniques; Male; Middle Aged; MutL Protein Homolog 1; MutS Homolog 2 Protein; Neoplasm Proteins - metabolism; Nuclear Proteins; O-Methylguanine-DNA Methyltransferase - metabolism; Prognosis; Proto-Oncogene Proteins - metabolism; Statistics, Nonparametric

O(6)-Methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that transfers methyl groups from O(6)-methylguanine to itself. Alkylation of DNA at the O(6) position of guanine is an important step in the induction of mutations in the organism by alkylating agents. The O(6)-methyl G:T mismat...