The substantia nigra of the human brain. I. Nigrosomes and the nigral matrix, a compartmental organization based on calbindin D(28K) immunohistochemistry

• Published in: Brain (London, England : 1878) Vol. 122 ( Pt 8); p. 1421
• Main Authors: Damier, P, Hirsch, E C, Agid, Y, Graybiel, A M
• Format: Journal Article
• Language: English
• Published: England 01.08.1999
• Subjects: Aged; Aged, 80 and over; Brain - cytology; Brain - metabolism; Calbindins; Dopamine - analysis; Humans; Immunohistochemistry; Nerve Tissue Proteins - analysis; Neurons - cytology; Neurons - metabolism; Parkinson Disease - metabolism; Parkinson Disease - pathology; Reference Values; S100 Calcium Binding Protein G - analysis; S100 Calcium Binding Protein G - metabolism; Substantia Nigra - cytology; Substantia Nigra - pathology; Tyrosine 3-Monooxygenase - analysis

Parkinson's disease is characterized by massive degeneration of dopamine-containing neurons in the midbrain. However, the vulnerability of these neurons is heterogeneous both across different midbrain dopamine-containing cell groups and within the substantia nigra, the brain structure most affe...