Efficacy and safety of ticlopidine monotherapy versus ticlopidine and aspirin after coronary artery stenting: follow-up results of a randomized study
A combined antiplatelet treatment with ticlopidine and aspirin has been accepted as standard pharmacological regimen after coronary artery stenting. No data of a randomized trial are available on ticlopidine monotherapy. This prospective, randomized monocenter trial investigates the role of ticlopid...
Saved in:
Published in | The Journal of invasive cardiology Vol. 13; no. 6; pp. 431 - 436 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.06.2001
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | A combined antiplatelet treatment with ticlopidine and aspirin has been accepted as standard pharmacological regimen after coronary artery stenting. No data of a randomized trial are available on ticlopidine monotherapy. This prospective, randomized monocenter trial investigates the role of ticlopidine monotherapy versus combined antiplatelet therapy with ticlopidine and aspirin in unselected patients undergoing coronary artery stenting. After successful placement of 378 coronary artery stents, two hundred and forty-three consecutive patients were randomly assigned to receive antiplatelet therapy with 2 x 250 mg ticlopidine (121 patients) or a combination of 2 x 250 mg ticlopidine plus 100 mg aspirin (122 patients) daily. The primary endpoint included the absence of death, cardiac events and vascular access-site complications during the in-hospital phase. Angiographic and clinical assessment was repeated at the 3-month follow-up exam. Two hundred and thirty-seven patients (97.5%) were free from cardiac and non-cardiac events. Stent thromboses were seen in 2 patients of the combined treatment group, while none were observed in the monotherapy group. No statistically significant differences were found between the 2 groups regarding the primary endpoint. Angiography performed in 210 patients (86.4%) at follow-up revealed a restenosis rate of 29.4% in the combined treatment group and 27.8% in the monotherapy group. Monotherapy with ticlopidine is as safe and effective as a combined regimen of ticlopidine plus aspirin after coronary artery stenting in an unselected patient population. These results need to be confirmed in a larger multicenter trial. |
---|---|
AbstractList | A combined antiplatelet treatment with ticlopidine and aspirin has been accepted as standard pharmacological regimen after coronary artery stenting. No data of a randomized trial are available on ticlopidine monotherapy. This prospective, randomized monocenter trial investigates the role of ticlopidine monotherapy versus combined antiplatelet therapy with ticlopidine and aspirin in unselected patients undergoing coronary artery stenting. After successful placement of 378 coronary artery stents, two hundred and forty-three consecutive patients were randomly assigned to receive antiplatelet therapy with 2 x 250 mg ticlopidine (121 patients) or a combination of 2 x 250 mg ticlopidine plus 100 mg aspirin (122 patients) daily. The primary endpoint included the absence of death, cardiac events and vascular access-site complications during the in-hospital phase. Angiographic and clinical assessment was repeated at the 3-month follow-up exam. Two hundred and thirty-seven patients (97.5%) were free from cardiac and non-cardiac events. Stent thromboses were seen in 2 patients of the combined treatment group, while none were observed in the monotherapy group. No statistically significant differences were found between the 2 groups regarding the primary endpoint. Angiography performed in 210 patients (86.4%) at follow-up revealed a restenosis rate of 29.4% in the combined treatment group and 27.8% in the monotherapy group. Monotherapy with ticlopidine is as safe and effective as a combined regimen of ticlopidine plus aspirin after coronary artery stenting in an unselected patient population. These results need to be confirmed in a larger multicenter trial. |
Author | Germing, A Lemke, B Deneke, T Bojara, W Machraoui, A von Dryander, S Grewe, P Lindstaedt, M Lawo, T Jaeger, D Barmeyer, J |
Author_xml | – sequence: 1 givenname: A surname: Machraoui fullname: Machraoui, A email: machraoui@t-online.de organization: Department of Internal Medicine, Diakonissenkrankenhaus, Flensburg, Germany. machraoui@t-online.de – sequence: 2 givenname: A surname: Germing fullname: Germing, A – sequence: 3 givenname: M surname: Lindstaedt fullname: Lindstaedt, M – sequence: 4 givenname: S surname: von Dryander fullname: von Dryander, S – sequence: 5 givenname: W surname: Bojara fullname: Bojara, W – sequence: 6 givenname: T surname: Lawo fullname: Lawo, T – sequence: 7 givenname: B surname: Lemke fullname: Lemke, B – sequence: 8 givenname: D surname: Jaeger fullname: Jaeger, D – sequence: 9 givenname: P surname: Grewe fullname: Grewe, P – sequence: 10 givenname: T surname: Deneke fullname: Deneke, T – sequence: 11 givenname: J surname: Barmeyer fullname: Barmeyer, J |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11385163$$D View this record in MEDLINE/PubMed |
BookMark | eNpVkLtOAzEQRV0EkQf8AnJFt9La3kdMh6IAkSLRQL1y1mMw8tqLH6DlP_hfHBEKqtFo7px7Z5ZoZp2FGVqQsqIF44zM0TKEt7KkhHFyjuaEsHVNGrZA31uldC_6CQsrcRAK4oSdwlH3xo1aagt4cNbFV_BinPAH-JDCv_FxUYRRe22xUBE87p13VvjM9LmdcIhgo7YvN1g5Y9xnkUbsISQTw9FLYJ8ZbtBfkCPEJKcLdKaECXB5qiv0fLd92jwU-8f73eZ2X4yE0liQui-rGtqWg2gpq0gjFZcV4XDgDaVS1lCvaVvRplVVy0i1hoOksuGU90RwYCt0_csdvXtPEGI36NCDMcKCS6FrS15mJ5qFVydhOgwgu9HrIR_Y_T2S_QCfR3OR |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM 7X8 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EndPage | 436 |
ExternalDocumentID | 11385163 |
Genre | Comparative Study Clinical Trial Randomized Controlled Trial Journal Article |
GroupedDBID | --- 0R~ 2WC 53G 5RE AAWTL ACGFO AENEX ALMA_UNASSIGNED_HOLDINGS CGR CUY CVF E3Z EBS ECM EIF EJD EMOBN F5P FRP GX1 HMP HZ~ J5H NPM O9- OK1 P2P TR2 W2D XSB 7X8 |
ID | FETCH-LOGICAL-p122t-15c045e779ea723416df9d419eb9622dd5e58274267f473148ebd2d6929c1a9e3 |
ISSN | 1042-3931 |
IngestDate | Fri Aug 16 09:31:52 EDT 2024 Sat Sep 28 07:37:38 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 6 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p122t-15c045e779ea723416df9d419eb9622dd5e58274267f473148ebd2d6929c1a9e3 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 ObjectType-News-3 content type line 23 |
PMID | 11385163 |
PQID | 70901222 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_70901222 pubmed_primary_11385163 |
PublicationCentury | 2000 |
PublicationDate | 2001-Jun 20010601 |
PublicationDateYYYYMMDD | 2001-06-01 |
PublicationDate_xml | – month: 06 year: 2001 text: 2001-Jun |
PublicationDecade | 2000 |
PublicationPlace | United States |
PublicationPlace_xml | – name: United States |
PublicationTitle | The Journal of invasive cardiology |
PublicationTitleAlternate | J Invasive Cardiol |
PublicationYear | 2001 |
References | 11385164 - J Invasive Cardiol. 2001 Jun;13(6):437-8 |
References_xml | |
SSID | ssj0021391 |
Score | 1.657059 |
Snippet | A combined antiplatelet treatment with ticlopidine and aspirin has been accepted as standard pharmacological regimen after coronary artery stenting. No data of... |
SourceID | proquest pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 431 |
SubjectTerms | Aged Aspirin - therapeutic use Coronary Disease - drug therapy Coronary Disease - surgery Drug Therapy, Combination Female Follow-Up Studies Humans Male Middle Aged Platelet Aggregation Inhibitors - therapeutic use Prospective Studies Stents Ticlopidine - therapeutic use Treatment Outcome |
Title | Efficacy and safety of ticlopidine monotherapy versus ticlopidine and aspirin after coronary artery stenting: follow-up results of a randomized study |
URI | https://www.ncbi.nlm.nih.gov/pubmed/11385163 https://search.proquest.com/docview/70901222 |
Volume | 13 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT9wwELaAA-qlKqUPSml94LZKlcSJk3CrYAEhHpddaW-REzvtVm2yWhKq5X_wf5mxnU0iUbXlEiXO2_PJnsc3Y0IOXSVdGUXc4aEEAyV3cSH30HVkwESGBrSXaYLsNT-fBhezcNZFdHV2SZ19ye-fzCt5jlShDeSKWbL_Idn1Q6EB9kG-sAUJw_afZDzG-g-4Xrv2fotCGXoFXlct5hIVSPgWm2O1GiEDo7kdnNalWjHYPm-XC8-xpAFS6TTZczUCFJRtVnQBoKl-O81iBEZ689PQQMQIpjtZ_Zrfg-7aVav90cHwol-d4k5ownyuebB9l_6VyL8vRdXMBx7WM03W-TZoQz8CKLVK1gN37h0A-WS50uk6nVO39Wj0mFd2EMaUIZbY2aEdpVkPjf0hN7DXKXv0RGHt65v0dHp5mU7Gs8km2WQecj_PZmsukA9qsGfKVpgX_9nc0GrH5BV5abuOfjXC3yEbqnxNtq8sI2KXPLQYoPDf1GCAVgXtCZn2MEANBgan8UaLAaoxQFsMUIMB2mLgiK4RQC0C8F2CdgigGgFvyPR0PDk-d-xSG87C8_3a8cIcdHsVRYkSkQ-aDZdFIgMvUVnCfV_KUIUxRvV5VAQRAxtaZdKXHJTr3BOJYm_JVlmV6j2hjMVhLt1AxCwOROgJwbKYizhOMOMk5nvkc9u3KQxlGJ8Spaqa2zRyEwz0-nvknenydGEqroCZCg8Fy-HDX-_dJy86SH0kW_WyUQegNtbZJy3yR_3EfC8 |
link.rule.ids | 315,786,790 |
linkProvider | Geneva Foundation for Medical Education and Research |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Efficacy+and+safety+of+ticlopidine+monotherapy+versus+ticlopidine+and+aspirin+after+coronary+artery+stenting%3A+follow-up+results+of+a+randomized+study&rft.jtitle=The+Journal+of+invasive+cardiology&rft.au=Machraoui%2C+A&rft.au=Germing%2C+A&rft.au=Lindstaedt%2C+M&rft.au=von+Dryander%2C+S&rft.date=2001-06-01&rft.issn=1042-3931&rft.volume=13&rft.issue=6&rft.spage=431&rft.epage=436&rft.externalDBID=NO_FULL_TEXT |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1042-3931&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1042-3931&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1042-3931&client=summon |