Transdermal formulations of deprenyl: guinea pig and pig models

• Published in: Neurobiology (Budapest, Hungary) Vol. 8; no. 2; p. 143
• Main Authors: Gaál, J, Szebeni, G, Székács, G, Fejér, E, Wágner, O, Szatmári, I, Magyar, K, Mezei, M
• Format: Journal Article
• Language: English
• Published: Hungary 2000
• Subjects: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical - methods; Guinea Pigs; Liposomes; Models, Animal; Monoamine Oxidase Inhibitors - pharmacokinetics; Selegiline - pharmacokinetics; Swine; Tissue Distribution; Tritium - pharmacokinetics

The efficacy of many drugs relies on their presence at the site of action over a period of time. The retardation or programmed release capability of the conventional dosage forms like oral and parenteral are limited and toxic and undesired side-effects may occur after their applications. These probl...