Two cases of advanced gastric cancer with diffuse carcinomatosis of the bone marrow showing a widespread osteoplastic bone metastasis

• Published in: Gan no rinsho. Japan journal of cancer clinics Vol. 36; no. 4; p. 551
• Main Authors: Kato, M, Sugano, K, Saito, E, Natomi, H, Takaku, F, Yaui, H, Tange, T, Fukusato, T, Machinami, R
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.03.1990
• Subjects: Adenocarcinoma, Mucinous - diagnostic imaging; Adenocarcinoma, Mucinous - pathology; Adenocarcinoma, Mucinous - secondary; Alkaline Phosphatase - blood; Bone and Bones - diagnostic imaging; Bone Marrow - pathology; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - pathology; Bone Neoplasms - secondary; Female; Humans; Male; Middle Aged; Ossification, Heterotopic - diagnostic imaging; Ossification, Heterotopic - pathology; Radionuclide Imaging; Stomach Neoplasms - enzymology; Stomach Neoplasms - pathology
• ISSN: 0021-4949

Reported are 2 cases of an advanced gastric cancer with a "diffuse carcinomatosis of the bone marrow" (DCMB) showing a widespread osteoplastic bone metastasis. In a DCBM, a widespread invasion of cancer cells to the bone marrow occurs, causing leukoerythroblastosis, anemia, and disseminated intravascular coagulation. The local reaction in the bone, namely being osteoplastic or osteolytic, has not been discussed in previous papers. Our cases were characterized by an extremely high serum alkaline phosphatase, a "superscan" view of the bone scintigram, and a diffuse osteoplastic bone metastasis with an osteoid increase. Thus we think there are DCBM subtypes with a diffuse osteoplastic bone metastasis.