Chromosomal assignments of three random RFLP loci defined by base-pair changes in MspI sites

• Published in: Molecular biology & medicine Vol. 1; no. 4; p. 415
• Main Authors: de Martinville, B, Schäfer, M, White, R, Francke, U
• Format: Journal Article
• Language: English
• Published: England 01.11.1983
• Subjects: Animals; Base Composition; Base Sequence; Chromosome Mapping; Chromosomes, Human - physiology; Cloning, Molecular; Cricetinae; Cricetulus; Deoxyribonuclease HpaII; DNA - genetics; DNA Restriction Enzymes - metabolism; Humans; Hybrid Cells - physiology; Lung; Nucleic Acid Hybridization; Plasmids; Polymorphism, Genetic

Three cloned single copy sequences isolated from a random partial plasmid library of human EcoRI-HindIII restriction fragments detect MspI site polymorphisms in human DNA. Since at least two of them have allele frequencies that make them suitable for family linkage studies, we have determined their...