Loco-regional cancer therapy for hepatic metastasis

• Published in: Gan to kagaku ryoho Vol. 18; no. 11; p. 1860
• Main Authors: Jinushi, K, Sawamura, A, Aogi, K, Toge, T
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.08.1991
• Subjects: Antineoplastic Combined Chemotherapy Protocols - administration & dosage; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Colonic Neoplasms - mortality; Colonic Neoplasms - pathology; Cyclophosphamide - administration & dosage; Doxorubicin - administration & dosage; Fluorouracil - administration & dosage; Hepatectomy - mortality; Humans; Infusions, Intra-Arterial; Liver Neoplasms - drug therapy; Liver Neoplasms - mortality; Liver Neoplasms - secondary; Stomach Neoplasms - mortality; Stomach Neoplasms - pathology; Survival Rate
• ISSN: 0385-0684

We undertook a clinical evaluation of chemotherapy for hepatic metastasis of gastric, colorectal and breast cancer. Between 1980 and 1989, chemotherapy for hepatic metastasis of gastric cancer was performed in 96 cases. Between 1973 and 1989, chemotherapy for hepatic metastasis of colorectal cancer and breast cancer was performed in 40 and 14 cases. (1) In hepatic metastasis of gastric cancer, the 50% survival period was 149 days in local injection therapy, 132 days in arterial infusion therapy and 117 days with no chemotherapy. There was no significant difference in the survival period in gastric cancer. (2) In hepatic metastasis of colorectal cancer, the 50% survival period was 445 days in arterial infusion therapy, 206 days in local injection therapy and 96 days with no chemotherapy. The survival period with hepatic metastasis of colorectal cancer that had undergone chemotherapy was longer than for no chemotherapy. (3) In hepatic metastasis of breast cancer, arterial infusion therapy was more effective, and the survival period was prolonged significantly.