Clinical reversal of drug resistance

• Published in: Current problems in cancer Vol. 19; no. 2; p. 65
• Main Author: Goldstein, L J
• Format: Journal Article
• Language: English
• Published: United States 01.03.1995
• Subjects: Animals; Antineoplastic Agents - therapeutic use; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism; ATP-Binding Cassette, Sub-Family B, Member 1 - physiology; Breast Neoplasms - metabolism; Cyclosporine - therapeutic use; Drug Resistance, Multiple - genetics; Female; Gastrointestinal Neoplasms - metabolism; Gene Expression; Gene Expression Regulation, Neoplastic - drug effects; Genital Neoplasms, Female - metabolism; Humans; Leukemia - metabolism; Lymphoma - metabolism; Male; Mice; Mice, Transgenic; Models, Genetic; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Research Design; Structure-Activity Relationship; Urogenital Neoplasms - metabolism; Verapamil - therapeutic use

Although combination chemotherapy has had a significant impact on survival for malignancies such as Hodgkin's disease, testicular cancer, and childhood acute leukemias, the majority of cancers are either initially resistant to chemotherapy (renal, colon, etc.) or are initially chemosensitive bu...