Efficacy of combined use of sodium thiosulfate in percutaneous isolated liver chemoperfusion of cisplatin under complete hepatic venous isolated and charcoal hemoperfusion

• Published in: Gan to kagaku ryoho Vol. 24; no. 12; p. 1781
• Main Authors: Kusunoki, N, Ku, Y, Tominaga, M, Iwasaki, T, Muramatsu, S, Sugimoto, T, Kuroda, Y
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.09.1997
• Subjects: Animals; Antidotes - administration & dosage; Antineoplastic Agents - administration & dosage; Charcoal - therapeutic use; Chemotherapy, Cancer, Regional Perfusion - methods; Cisplatin - administration & dosage; Dogs; Hemoperfusion; Hepatic Veins; Thiosulfates - administration & dosage

We herein evaluated the efficacy of combined use of sodium thiosulfate (STS) in isolated liver chemoperfusion of cisplatin (CDDP) under complete hepatic venous isolation and charcoal hemoperfusion (HVI.CHP). Dogs were divided into two groups; group I (n = 5), CDDP (4 mg/kg) + STS (4 g/body) and grou...