The effect of nitric oxide synthase inhibitor on reperfusion injury to the brain under hypothermic circulatory arrest

• Published in: [Zasshi] [Journal]. Nihon Kyobu Geka Gakkai Vol. 45; no. 5; p. 687
• Main Authors: Segawa, D, Hatori, N, Yoshizu, H, Tanaka, S
• Format: Journal Article
• Language: Japanese
• Published: Japan 01.05.1997
• Subjects: Animals; Brain - metabolism; Cerebrovascular Circulation; Heart Arrest, Induced; Hypothermia, Induced; NG-Nitroarginine Methyl Ester - therapeutic use; Nitric Oxide - biosynthesis; Nitric Oxide Synthase - antagonists & inhibitors; Reperfusion Injury - metabolism; Reperfusion Injury - prevention & control; Swine

The effect of nitric oxide synthase inhibitor-NG-nitro-L-argine methyl ester (L-NAME)-on reperfusion injury of the brain under deep hypothermic circulatory arrest was experimentally investigated in sixteen piglets weighing about 30 kg. Cardiopulmonary bypass was established and animals were cooled t...