Late events in chondrocyte differentiation: hypertrophy, type X collagen synthesis and matrix calcification

• Published in: In vivo (Athens) Vol. 5; no. 5; p. 533
• Main Authors: Schmid, T M, Bonen, D K, Luchene, L, Linsenmayer, T F
• Format: Journal Article
• Language: English
• Published: Greece 01.09.1991
• Subjects: Animals; Birds; Calcification, Physiologic; Cartilage - embryology; Cell Differentiation; Collagen - biosynthesis; Collagen - ultrastructure; Egg Shell - metabolism

During endochondral bone formation chondrocytes pass through several stages of differentiation which are characterized by cell proliferation, matrix synthesis and cell hypertrophy. Type X collagen is synthesized in vivo after chondrocytes have become hypertrophic, but before abundant mineral accumul...