Modulatory role of nitric oxide on angiotensins vasoconstriction

• Published in: Romanian journal of physiology : physiological sciences Vol. 33; no. 1-4; p. 83
• Main Authors: Haulică, I, Todiraş, M, Brăiloiu, E, Bălţatu, O
• Format: Journal Article
• Language: English
• Published: Romania 01.01.1996
• Subjects: Angiotensin I - drug effects; Angiotensin I - physiology; Angiotensin II - drug effects; Angiotensin II - physiology; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Aorta - drug effects; Aorta - physiology; Captopril - pharmacology; Enzyme Inhibitors - pharmacology; Male; Muscle, Smooth, Vascular - drug effects; NG-Nitroarginine Methyl Ester - pharmacology; Nifedipine - pharmacology; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - physiology; Rats; Rats, Wistar; Saralasin - pharmacology; Vasoconstriction - drug effects; Vasodilator Agents - pharmacology

Using aortic rings from male Wistar rats, we studied the influence of nitric oxide (NO) on the vascular reactivity to angiotensins. The inhibition of NO-synthesis by L-NAME produced on both intact and desendothelised rings an augmentation of vascular reactivity to angiotensins. NO inhibition did not...