Malaria chemosuppression during pregnancy. IV. Its effects on the newborn's passive malaria immunity

• Published in: Tropical and geographical medicine Vol. 45; no. 4; p. 150
• Main Authors: Mutabingwa, T K, Malle, L N, Verhave, J P, Eling, W M, Meuwissen, J H, de Geus, A
• Format: Journal Article
• Language: English
• Published: Netherlands 1993
• Subjects: Animals; Antibodies, Protozoan - blood; Cesarean Section; Chloroquine - pharmacology; Chloroquine - therapeutic use; Drug Therapy, Combination; Enzyme-Linked Immunosorbent Assay; Female; Fetal Blood - drug effects; Fetal Blood - parasitology; Humans; Immunity, Maternally-Acquired; Infant, Newborn - blood; Infant, Newborn - immunology; Malaria - blood; Malaria - drug therapy; Malaria - parasitology; Malaria - prevention & control; Organ Size; Parity; Placenta - anatomy & histology; Placenta - parasitology; Plasmodium - immunology; Pregnancy; Pregnancy Complications, Parasitic - blood; Pregnancy Complications, Parasitic - drug therapy; Pregnancy Complications, Parasitic - parasitology; Pregnancy Complications, Parasitic - prevention & control; Pregnancy Outcome; Proguanil - pharmacology; Proguanil - therapeutic use

The effect of malaria prophylaxis during pregnancy on the levels of cord blood anti-sporozoite antibodies was investigated in 203 newborns in Muheza, Tanzania. Mothers of 76 newborns had received prophylaxis with proguanil daily (PROG), 66 chloroquine once weekly (CQ), and 61 got a combination of th...