DNA-grading of malignant lymphomas. II. Correlation with clinical parameters

The clinical significance of the DNA-malignancy grade (DNA-MG) was tested in 90 malignant lymphoma patients. Feulgen stained imprint smears from freshly cut lymph-nodes were investigated. DNA measurements were performed using various cytophotometers. The scalar DNA-MG, ranging from 0.1 to 3.0, was c...

Full description

Saved in:
Bibliographic Details
Published inAnticancer research Vol. 6; no. 5; p. 1217
Main Authors Böcking, A, Chatelain, R, Auffermann, W, Löhr, G W, Reif, M, Rossner, R, Becker, H
Format Journal Article
LanguageEnglish
Published Greece 01.09.1986
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Child
Child, Preschool
DNA - analysis
Female
Humans
Lymphoma, Non-Hodgkin - genetics
Lymphoma, Non-Hodgkin - pathology
Male
Middle Aged
Neoplasm Staging - methods
Online AccessGet more information

Cover

More Information
Summary:The clinical significance of the DNA-malignancy grade (DNA-MG) was tested in 90 malignant lymphoma patients. Feulgen stained imprint smears from freshly cut lymph-nodes were investigated. DNA measurements were performed using various cytophotometers. The scalar DNA-MG, ranging from 0.1 to 3.0, was calculated from the variance of the tumor cells around the 2c peak. Except for the CLL, all entities of the Kiel classification for non-Hodgkin's malignant lymphomas showed considerable variation of the DNA-MGs. The DNA-MG, the age of the patients and the response to treatment were seen to have a significant influence on the survival time of non-Hodgkin's lymphoma patients. In high grade lymphoma patients of the Kiel classification, the DNA-MG was found to provide additional prognostic information. The DNA-MG was strongly correlated with the ESR, low albumin concentration, low lymphocyte counts in peripheral blood, clinical and pathological staging, and the response to treatment.
ISSN:0250-7005