The influence of the solvent on the toxicity and radioprotective effect of thiophosphate WR2721 in mice

• Published in: Strahlentherapie und Onkologie Vol. 162; no. 2; p. 134
• Main Authors: Mönig, H, Sedlmeier, H, Messerschmidt, O
• Format: Journal Article
• Language: English
• Published: Germany 01.02.1986
• Subjects: Amifostine - therapeutic use; Amifostine - toxicity; Animals; Hydrogen-Ion Concentration; Male; Mice; Organothiophosphorus Compounds - therapeutic use; Radiation Injuries, Experimental - prevention & control; Solvents - pharmacology

The influence of various solvents on the toxicity as well as the protective efficiency of thiophosphate WR2721 in X-irradiated male mice is described. The use of Sörensen buffer as solvent with a pH-value of 7.4 leads to a statistically significant lower lethality in animals than aqua bidest. Howeve...