Human apolipoprotein E epsilon 4 expression impairs cerebral vascularization and blood-brain barrier function in mice

• Published in: Journal of cerebral blood flow and metabolism Vol. 35; no. 1; pp. 86 - 94
• Main Authors: Alata, Wael, Ye, Yue, St-Amour, Isabelle, Vandal, Milene, Calon, Frederic
• Format: Journal Article
• Language: English
• Published: 01.01.2015

Human apolipoprotein E (APOE) exists in three isoforms epsilon 2, epsilon 3, and epsilon 4, of which APOE4 is the main genetic risk factor of Alzheimer's disease (AD). As cerebrovascular defects are associated with AD, we tested whether APOE genotype has an impact on the integrity and function...