APO epsilon 4 is associated with enhanced in vivo innate immune responses in human subjects

• Published in: Journal of allergy and clinical immunology Vol. 134; no. 1; pp. 127 - 134.e9
• Main Authors: Gale, Stephen C, Gao, Li, Mikacenic, Carmen, Coyle, Susette M, Rafaels, Nicholas, Murray Dudenkov, Tanda, Madenspacher, Jennifer H, Draper, David W, Ge, William, Aloor, Jim J, Azzam, Kathleen M, Lai, Lihua, Blackshear, Perry J, Calvano, Steven E, Barnes, Kathleen C, Lowry, Stephen F, Corbett, Siobhan, Wurfel, Mark M, Fessler, Michael B
• Format: Journal Article
• Language: English
• Published: 01.07.2014

Background The genetic determinants of the human innate immune response are poorly understood. Apolipoprotein (Apo) E, a lipid-trafficking protein that affects inflammation, has well-described wild-type ( epsilon 3) and disease-associated ( epsilon 2 and epsilon 4) alleles, but its connection to hum...