pH-Responsive Near Infrared Light Triggered Hydroxyapatite Nanoparticles for Targeted Photothermal Cancer Therapy

• Published in: bioRxiv
• Main Authors: Loganathan Palanikumar, Faten Mansoor Yasin, Munkhjargal, Itgel, Boitet, Maylis, Ali, Liaqat, Muhammed Shiraz Ali, Straubinger, Rainer, Francisco Nicolas Barrera, Magzoub, Mazin
• Format: Paper Journal Article
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 26.02.2025; Cold Spring Harbor Laboratory
• Subjects: Acidity; Antitumor activity; Cancer therapies; Cholesterol; Dyes; Fluorophores; Hydroxyapatite; Hyperthermia; Internalization; Macrophages; Microenvironments; Nanoparticles; Toxicity; Tumor cells; Tumors

Photothermal therapy (PTT) has emerged as an effective cancer treatment strategy, which utilizes photothermal agents that accumulate at tumor sites and induce localized hyperthermia when irradiated. Near-infrared II (NIR II) fluorophores, such as the polymethine cyanine-based photothermal dye IR1061...