Selective Killing of Adriamycin-Resistant (G sub(2) Checkpoint-Deficient and MRP1-Expressing) Cancer Cells by Docetaxel

• Published in: Cancer research (Chicago, Ill.) Vol. 65; no. 10; pp. 4401 - 4407
• Main Authors: Demidenko, Zoya N, Halicka, Dorota, Kunicki, Jan, McCubrey, James A, Darzynkiewicz, Zbigniew, Blagosklonny, Mikhail V
• Format: Journal Article
• Language: English
• Published: 15.05.2005

Chemotherapy of cancer is limited by toxicity to normal cells. Drug resistance further limits the therapy. Here, we investigated selective killing of drug-resistant cancer cells by antagonistic drug combinations, which can spare (because of drug antagonism) normal cells. We used paired cell lines th...