'Ground truth' for selection on CCR5- Delta 32

• Published in: Trends in genetics Vol. 22; no. 6; pp. 293 - 296
• Main Authors: Hedrick, P W, Verrelli, B C
• Format: Journal Article
• Language: English
• Published: 01.06.2006

A much-celebrated story of positive selection in the human genome is the 32-bp deletion in the chemokine receptor CCR5, a variant that confers resistance to AIDS. This variant was postulated to be a relatively recent response to plague or smallpox. New research shows that the frequency of CCR5- Delt...