Core 2 Branching beta 1,6-N-Acetylglucosaminyltransferase and High Endothelial Venule-restricted Sulfotransferase Collaboratively Control Lymphocyte Homing

• Published in: The Journal of biological chemistry Vol. 279; no. 4; pp. 3058 - 3067
• Main Authors: Hiraoka, N, Kawashima, H, Petryniak, B, Nakayama, J, Mitoma, J, Marth, J D, Lowe, J B, Fukuda, M
• Format: Journal Article
• Language: English
• Published: 23.01.2004
• Subjects: L-selectin ligand sulfotransferase; lymphocyte homing

L-selectin mediates lymphocyte homing by facilitating lymphocyte adhesion to carbohydrate ligands expressed on high endothelial venules (HEV) of the secondary lymphoid organs. Previous studies demonstrated that L-selectin ligand sulfotransferase (LSST) forms 6-sulfo sialyl Lewis x (sLe super(x)) on...