Novel Controlled-Release Lemna-Derived IFN- alpha 2b (Locteron): Pharmacokinetics, Pharmacodynamics, and Tolerability in a Phase I Clinical Trial

• Published in: Journal of interferon & cytokine research Vol. 28; no. 2; pp. 113 - 122
• Main Authors: De Leede, LGJ, Humphries, JE, Bechet, A C, Van Hoogdalem, EJ, Verrijk, R, Spencer, D G
• Format: Journal Article
• Language: English
• Published: 01.02.2008

Locteron, a newly developed controlled-release formulation of Lemna-derived free (unpegylated) recombinant interferon- alpha 2b (IFN- alpha 2b, Biolex Therapeutics, Pittsboro, NC) in poly(ether-ester) microspheres (Poly-Active, OctoPlus N.V., Leiden, the Netherlands), was evaluated in 27 volunteers...