Non-cytotoxic Cobra Cardiotoxin A5 Binds to alpha v beta 3 Integrin and Inhibits Bone Resorption: IDENTIFICATION OF CARDIOTOXINS AS NON-RGD INTEGRIN-BINDING PROTEINS OF THE Ly-6 FAMILY

• Published in: The Journal of biological chemistry Vol. 281; no. 12; pp. 7937 - 7945
• Main Authors: Wu, Po-Long, Lee, Shao-Chen, Chuang, Chia-Chen, Mori, Seiji, Akakura, Nobuaki, Wu, Wen-guey, Takada, Yoshikazu
• Format: Journal Article
• Language: English
• Published: 24.03.2006
• Subjects: Elapidae

Severe tissue necrosis with a retarded wound healing process is a major symptom of a cobra snakebite. Cardiotoxins (CTXs) are major components of cobra venoms that belong to the Ly-6 protein family and are implicated in tissue damage. The interaction of the major CTX from Taiwan cobra, i.e. CTX A3,...