Double knockdown of alpha 1,6-fucosyltransferase (FUT8) and GDP-mannose 4,6-dehydratase (GMD) in antibody-producing cells: a new strategy for generating fully non-fucosylated therapeutic antibodies with enhanced ADCC

• Published in: BMC biotechnology Vol. 7; p. 84
• Main Authors: Imai-Nishiya, Harue, Mori, Katsuhiro, Inoue, Miho, Wakitani, Masako, Iida, Shigeru, Shitara, Kenya, Satoh, Mitsuo
• Format: Journal Article
• Language: English
• Published: 30.11.2007

Background Antibody-dependent cellular cytotoxicity (ADCC) is greatly enhanced by the absence of the core fucose of oligosaccharides attached to the Fc, and is closely related to the clinical efficacy of anticancer activity in humans in vivo. Unfortunately, all licensed therapeutic antibodies and al...