Copper-Catalyzed Intramolecular Desymmetric Aryl CO Coupling for the Enantioselective Construction of Chiral Dihydrobenzofurans and Dihydrobenzopyrans

• Published in: Angewandte Chemie International Edition Vol. 54; no. 30; pp. 8805 - 8808
• Main Authors: Yang, Wenqiang, Liu, Yangyuan, Zhang, Shasha, Cai, Qian
• Format: Journal Article
• Language: English
• Published: WEINHEIM Wiley 20.07.2015; Wiley Subscription Services, Inc
• Edition: International ed. in English
• Subjects: Chemistry; Chemistry, Multidisciplinary; Copper; Physical Sciences; Science & Technology; SILYL PROTECTION; PALLADIUM; desymmetrization; ASYMMETRIC-SYNTHESIS; TERT-ALKYLAMINES; 3-dihydrobenzofuran; ANALOGS; NATURAL-PRODUCTS; O-arylation; BOND FORMATION; OLEFIN METATHESIS; asymmetric catalysis; ALCOHOLS; 2; copper; CYCLIZATION

O-Heterocyclic structures such as 2,3-dihydrobenzofurans are key motifs in many natural compounds and pharmaceuticals. Enantioselective formation of chiral dihydrobenzofurans and analogues was achieved through a copper-catalyzed desymmetrization strategy with a chiral cyclic 1,2-diamine. A broad ran...