Enhanced motivation to alcohol in transgenic mice expressing human [alpha]-synuclein

• Published in: Journal of neurochemistry Vol. 143; no. 3; p. 294
• Main Authors: Rotermund, Carola, Reolon, Gustavo K, Leixner, Sarah, Boden, Cindy, Bilbao, Ainhoa, Kahle, Philipp J
• Format: Journal Article
• Language: English
• Published: New York Blackwell Publishing Ltd 01.11.2017
• Subjects: Addictions; Alcoholic beverages; Alcoholism; Amygdala; Brain; Deprivation; Drug abuse; Drug self-administration; Environmental effects; Ethanol; Genome-wide association studies; Genomes; Genotypes; Human behavior; Mice; Motivation; Movement disorders; Neurodegenerative diseases; Nucleus accumbens; Operant conditioning; Parkinson's disease; Rodents; Synuclein; Transgenic animals; Transgenic mice

[alpha]-Synuclein ([alpha]SYN) is the neuropathological hallmark protein of Parkinson's disease (PD) and related neurodegenerative disorders. Moreover, the gene encoding [alpha]SYN (SNCA) is a major genetic contributor to PD. Interestingly, independent genome-wide association studies also ident...