Focal Adhesion Kinase (FAK) inhibition induces membrane accumulation of aquaporin2 (AQP2) through endocytosis inhibition and actin depolymerization in renal epithelial cells

• Published in: bioRxiv
• Main Authors: Tchakal-Mesbahi, Asma, He, Jinzhao, Zhu, Shuai, Huang, Ming, Fukushima, Kazuhiko, Bouley, Richard, Brown, Dennis, Lu, Hua A J
• Format: Journal Article
• Language: English
• Published: United States Cold Spring Harbor Laboratory 09.10.2024

Cellular trafficking of the water channel aquaporin 2 (AQP2) is regulated by the actin cytoskeleton in collecting duct principal cells (PC) to maintain proper water balance in animals. Critical actin depolymerization/polymerization events are involved in both constitutive AQP2 recycling, and the pat...