Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population
Leukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism of LTC4S gene and asthma, asthma phen...
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Published in | Mædica Vol. 10; no. 2; pp. 91 - 96 |
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Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
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Romania
Tarus Media
01.06.2015
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Abstract | Leukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism of LTC4S gene and asthma, asthma phenotypes (aspirin intolerant/tolerant asthma) and different characteristics of the patients.
We included 106 patients with asthma (60 with aspirin tolerant asthma - ATA, 46 with aspirin intolerant asthma - AIA) and 103 controls. All the subjects were genotyped for LTC4S-444 A/C by Real-Time PCR. We assessed the association of LTC4S promoter polymorphism with asthma and its phenotypes and with clinical and biological characteristics of asthmatic patients.
We did not find a significant association between the studied polymorphism and asthma, but the minor allele tended to be more frequent in AIA patients. We found a significant association between the minor allele C and lower levels of serum total immunoglobulin E and eosinophils, suggesting a possible role of -444A/C LTC4S polymorphism as modulating factor of allergic inflammation in asthma.
The results show that LTC4S -444A/C SNP is not associated with susceptibility to asthma in Romanian patients, but could influence asthma phenotype, namely aspirin intolerant asthma. |
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AbstractList | Leukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism of LTC4S gene and asthma, asthma phenotypes (aspirin intolerant/tolerant asthma) and different characteristics of the patients.
We included 106 patients with asthma (60 with aspirin tolerant asthma - ATA, 46 with aspirin intolerant asthma - AIA) and 103 controls. All the subjects were genotyped for LTC4S-444 A/C by Real-Time PCR. We assessed the association of LTC4S promoter polymorphism with asthma and its phenotypes and with clinical and biological characteristics of asthmatic patients.
We did not find a significant association between the studied polymorphism and asthma, but the minor allele tended to be more frequent in AIA patients. We found a significant association between the minor allele C and lower levels of serum total immunoglobulin E and eosinophils, suggesting a possible role of -444A/C LTC4S polymorphism as modulating factor of allergic inflammation in asthma.
The results show that LTC4S -444A/C SNP is not associated with susceptibility to asthma in Romanian patients, but could influence asthma phenotype, namely aspirin intolerant asthma. INTRODUCTIONLeukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study was to investigate the association between the -444A/C polymorphism of LTC4S gene and asthma, asthma phenotypes (aspirin intolerant/tolerant asthma) and different characteristics of the patients. MATERIAL AND METHODSWe included 106 patients with asthma (60 with aspirin tolerant asthma - ATA, 46 with aspirin intolerant asthma - AIA) and 103 controls. All the subjects were genotyped for LTC4S-444 A/C by Real-Time PCR. We assessed the association of LTC4S promoter polymorphism with asthma and its phenotypes and with clinical and biological characteristics of asthmatic patients. RESULTSWe did not find a significant association between the studied polymorphism and asthma, but the minor allele tended to be more frequent in AIA patients. We found a significant association between the minor allele C and lower levels of serum total immunoglobulin E and eosinophils, suggesting a possible role of -444A/C LTC4S polymorphism as modulating factor of allergic inflammation in asthma. CONCLUSIONThe results show that LTC4S -444A/C SNP is not associated with susceptibility to asthma in Romanian patients, but could influence asthma phenotype, namely aspirin intolerant asthma. |
Author | Meirosu, Mihaela Berghea, Elene Camelia Popa, Olivia M Berghea, Florian Dutescu, Monica I Farcasanu, Ileana C Popa, Luis O Bara, Constantin |
Author_xml | – sequence: 1 givenname: Elene Camelia surname: Berghea fullname: Berghea, Elene Camelia organization: Department of Immunology and Pathophysiology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania – sequence: 2 givenname: Luis O surname: Popa fullname: Popa, Luis O organization: Department of Molecular Biology, "Grigore Antipa" National Museum of Natural History, Bucharest, Romania – sequence: 3 givenname: Monica I surname: Dutescu fullname: Dutescu, Monica I organization: "Prof. Dr. C. T. Nicolau" National Institute of Blood Transfusion, Bucharest, Romania – sequence: 4 givenname: Mihaela surname: Meirosu fullname: Meirosu, Mihaela organization: ICA Research and Development, Bucharest, Romania – sequence: 5 givenname: Ileana C surname: Farcasanu fullname: Farcasanu, Ileana C organization: Faculty of Chemistry, University of Bucharest, Bucharest, Romania – sequence: 6 givenname: Florian surname: Berghea fullname: Berghea, Florian organization: Department of Rheumatology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania – sequence: 7 givenname: Constantin surname: Bara fullname: Bara, Constantin organization: Department of Immunology and Pathophysiology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania – sequence: 8 givenname: Olivia M surname: Popa fullname: Popa, Olivia M organization: Department of Immunology and Pathophysiology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania |
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Snippet | Leukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have reported... INTRODUCTIONLeukotriene C4 synthase (LTC4S) gene -444A/C polymorphism has been implicated in susceptibility to asthma, but a large number of studies have... |
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Title | Association of Leukotriene C4 Synthase A-444C Polymorphism with Asthma and Asthma Phenotypes in Romanian Population |
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