The Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension is Regulated through a MiR-124/PTBP1/PKM Axis

• Published in: Circulation (New York, N.Y.) Vol. 136; no. 25; pp. 2468 - 2485
• Main Authors: Zhang, Hui, Wang, Daren, Li, Min, Plecitá-Hlavatá, Lydie, D’Alessandro, Angelo, Tauber, Jan, Riddle, Suzette, Kumar, Sushil, Flockton, Amanda, McKeon, B. Alexandre, Frid, Maria G., Reisz, Julie A., Caruso, Paola, El Kasmi, Karim C., Ježek, Petr, Morrell, Nicholas W., Hu, Cheng-Jun, Stenmark, Kurt R.
• Format: Journal Article
• Language: English
• Published: by the American College of Cardiology Foundation and the American Heart Association, Inc 10.10.2017

BACKGROUND—An emerging 'metabolic theory' of pulmonary hypertension (PH) suggests that cellular and mitochondrial metabolic dysfunction underlies the pathology of this disease. We and others have previously demonstrated the existence of hyper-proliferative, apoptosis-resistant, pro-inflamm...