T cells expressing chimeric antigen receptors can cause anaphylaxis in humans

• Published in: Cancer immunology research Vol. 1; no. 1; p. 26
• Main Authors: Maus, Marcela V, Haas, Andrew R, Beatty, Gregory L, Albelda, Steven M, Levine, Bruce L, Liu, Xiaojun, Zhao, Yangbing, Kalos, Michael, June, Carl H
• Format: Journal Article
• Language: English
• Published: United States 01.07.2013
• Subjects: Aged, 80 and over; Anaphylaxis - etiology; Anaphylaxis - immunology; Animals; Chimerism; Compassionate Use Trials; GPI-Linked Proteins - genetics; GPI-Linked Proteins - immunology; Humans; Immunoglobulin Fragments - biosynthesis; Immunoglobulin Fragments - genetics; Immunoglobulin Fragments - immunology; Immunotherapy, Adoptive - adverse effects; Immunotherapy, Adoptive - methods; Male; Mesothelin; Mesothelioma - immunology; Mesothelioma - therapy; Mice; Pleural Neoplasms - immunology; Pleural Neoplasms - therapy; Receptors, Antigen, T-Cell - biosynthesis; Receptors, Antigen, T-Cell - immunology; Recombinant Fusion Proteins - biosynthesis; Recombinant Fusion Proteins - genetics; Recombinant Fusion Proteins - immunology; T-Lymphocytes - immunology

T cells can be redirected to overcome tolerance to cancer by engineering with integrating vectors to express a chimeric antigen receptor (CAR). In preclinical models, we have previously shown that transfection of T cells with mRNA coding for a CAR is an alternative strategy that has antitumor effica...