Expressions of IL-1α and MMP-9 in degenerated lumbar disc tissues and their clinical significance
To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance. Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according...
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Published in | European review for medical and pharmacological sciences Vol. 21; no. 18; p. 4007 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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01.09.2017
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Abstract | To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance.
Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according to the magnetic resonance imaging (MRI) results: protrusion group, extrusion group, and free group. The degenerated intervertebral disc tissues were taken, and the normal intervertebral disc tissues of 20 patients received the operative treatment due to lumbar bursting fracture, and were selected as the control group. The bone mineral densities of all patients were measured. The mRNA and protein expression levels of MMP-9 and IL-1α were detected via Real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively.
The bone mass of patients with lumbar disc degeneration was significantly decreased compared with that of the control group, and the bone mass was decreased more significantly in a free group than that in protrusion group. The mRNA and protein levels in IL-1α and MMP-9 of patients with lumbar disc degeneration were significantly increased compared with those in control group; the mRNA and protein levels in IL-1α and MMP-9 of extrusion group and free group were significantly higher than those in protrusion group, and the mRNA and protein levels in IL-1α and MMP-9 of free group were significantly higher than those in extrusion group.
The levels of IL-1α and MMP-9 in degenerated lumbar disc tissues are higher than normal levels, and the increasing levels are positively correlated with the disease condition. |
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AbstractList | To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance.
Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according to the magnetic resonance imaging (MRI) results: protrusion group, extrusion group, and free group. The degenerated intervertebral disc tissues were taken, and the normal intervertebral disc tissues of 20 patients received the operative treatment due to lumbar bursting fracture, and were selected as the control group. The bone mineral densities of all patients were measured. The mRNA and protein expression levels of MMP-9 and IL-1α were detected via Real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively.
The bone mass of patients with lumbar disc degeneration was significantly decreased compared with that of the control group, and the bone mass was decreased more significantly in a free group than that in protrusion group. The mRNA and protein levels in IL-1α and MMP-9 of patients with lumbar disc degeneration were significantly increased compared with those in control group; the mRNA and protein levels in IL-1α and MMP-9 of extrusion group and free group were significantly higher than those in protrusion group, and the mRNA and protein levels in IL-1α and MMP-9 of free group were significantly higher than those in extrusion group.
The levels of IL-1α and MMP-9 in degenerated lumbar disc tissues are higher than normal levels, and the increasing levels are positively correlated with the disease condition. |
Author | Tang, W-J Zou, K Che, B Wang, K Li, P-B |
Author_xml | – sequence: 1 givenname: P-B surname: Li fullname: Li, P-B email: 568414248@qq.com organization: Department of Orthopedics, General Hospital of the Yangtze River Shipping and Wuhan Brain Hospital, Wuhan, Hubei Province, China. 568414248@qq.com – sequence: 2 givenname: W-J surname: Tang fullname: Tang, W-J – sequence: 3 givenname: K surname: Wang fullname: Wang, K – sequence: 4 givenname: K surname: Zou fullname: Zou, K – sequence: 5 givenname: B surname: Che fullname: Che, B |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29028103$$D View this record in MEDLINE/PubMed |
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SubjectTerms | Adult Bone Density Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Humans Interleukin-1alpha - analysis Interleukin-1alpha - genetics Interleukin-1alpha - metabolism Intervertebral Disc Degeneration - diagnosis Intervertebral Disc Degeneration - diagnostic imaging Intervertebral Disc Degeneration - surgery Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - metabolism Magnetic Resonance Imaging Male Matrix Metalloproteinase 9 - analysis Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism Middle Aged |
Title | Expressions of IL-1α and MMP-9 in degenerated lumbar disc tissues and their clinical significance |
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