Artificial oxygen carriers and red blood cell substitutes: A historic overview and recent developments toward military and clinical relevance

• Published in: The journal of trauma and acute care surgery Vol. 87; no. 1S Suppl 1; p. S48
• Main Authors: Bialas, Christopher, Moser, Christopher, Sims, Carrie A
• Format: Journal Article
• Language: English
• Published: United States 01.07.2019
• Subjects: Adult; Armed Conflicts - history; Blood Substitutes - administration & dosage; Female; History, 20th Century; History, 21st Century; Humans; Male; Middle Aged; Military Personnel - statistics & numerical data; Oxygen - administration & dosage; Quality Improvement; Resuscitation - methods; Resuscitation - mortality; Shock, Hemorrhagic - mortality; Shock, Hemorrhagic - physiopathology; Shock, Hemorrhagic - therapy; Treatment Outcome

Packed red blood cells are a critical component in the resuscitation of hemorrhagic shock. The availability of donor-derived blood products, however, suffers from issues of supply, immunogenicity, and pathogenic contamination. Deployment in remote or austere environments, such as the battlefield, is...