Livin Regulates H2A.X Y142 Phosphorylation and Promotes Autophagy in Colon Cancer Cells via a Novel Kinase Activity

• Published in: Frontiers in oncology Vol. 9; p. 1233
• Main Authors: Ge, Yang, Liu, Bao-Lin, Cui, Jun-Peng, Li, Shu-Qiang
• Format: Journal Article
• Language: English
• Published: Switzerland 14.11.2019
• Subjects: autophagy; colon cancer cells; phosphorylation; Livin; H2A.X

To investigate Livin-mediated regulation of H2A.X phosphorylation via a novel kinase activity and its effect on autophagy in colon cancer cells. The interaction between Livin and H2A.X was tested by immunoprecipitation. H2A.X-/- HCT116 cells were transfected with human influenza hemagglutinin (HA)-t...