A high-avidity biosensor reveals plasma membrane PI(3,4)P 2 is predominantly a class I PI3K signaling product

• Published in: The Journal of cell biology Vol. 218; no. 3; p. 1066
• Main Authors: Goulden, Brady D, Pacheco, Jonathan, Dull, Allyson, Zewe, James P, Deiters, Alexander, Hammond, Gerald R V
• Format: Journal Article
• Language: English
• Published: United States 04.03.2019
• Subjects: Animals; Biosensing Techniques; Cell Membrane - genetics; Cell Membrane - metabolism; Chlorocebus aethiops; COS Cells; HeLa Cells; Humans; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositol Phosphates - genetics; Phosphatidylinositol Phosphates - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Signal Transduction

Class I phosphoinositide 3-OH kinase (PI3K) signaling is central to animal growth and metabolism, and pathological disruption of this pathway affects cancer and diabetes. However, the specific spatial/temporal dynamics and signaling roles of its minor lipid messenger, phosphatidylinositol (3,4)-bisp...