Myocardial T 1 -mapping at 3T using saturation-recovery: reference values, precision and comparison with MOLLI

• Published in: Journal of cardiovascular magnetic resonance Vol. 18; no. 1; p. 84
• Main Authors: Weingärtner, Sebastian, Meßner, Nadja M, Budjan, Johannes, Loßnitzer, Dirk, Mattler, Uwe, Papavassiliu, Theano, Zöllner, Frank G, Schad, Lothar R
• Format: Journal Article
• Language: English
• Published: England 18.11.2016
• Subjects: Adult; Contrast Media - administration & dosage; Female; Healthy Volunteers; Heart - diagnostic imaging; Humans; Image Interpretation, Computer-Assisted - methods; Image Interpretation, Computer-Assisted - standards; Magnetic Resonance Imaging - instrumentation; Magnetic Resonance Imaging - methods; Magnetic Resonance Imaging - standards; Male; Meglumine - administration & dosage; Myocardium; Observer Variation; Organometallic Compounds - administration & dosage; Phantoms, Imaging; Predictive Value of Tests; Reference Values; Reproducibility of Results; Young Adult; 3T; SAPPHIRE; Cardiovascular magnetic resonance; MOLLI; Saturation-recovery T1-mapping; Reference values; SASHA
• ISSN: 1532-429X
• DOI: 10.1186/s12968-016-0302-x

Myocardial T -mapping recently emerged as a promising quantitative method for non-invasive tissue characterization in numerous cardiomyopathies. Commonly performed with an inversion-recovery (IR) magnetization preparation at 1.5T, the application at 3T has gained due to increased quantification precision. Alternatively, saturation-recovery (SR) T -mapping has recently been introduced at 1.5T for improved accuracy. Thus, the purpose of this study is to investigate the robustness and precision of SR T -mapping at 3T and to establish accurate reference values for native T -times and extracellular volume fraction (ECV) of healthy myocardium. Balanced Steady-State Free-Precession (bSSFP) Saturation-Pulse Prepared Heart-rate independent Inversion-REcovery (SAPPHIRE) and Saturation-recovery Single-SHot Acquisition (SASHA) T -mapping were compared with the Modified Look-Locker inversion recovery (MOLLI) sequence at 3T. Accuracy and precision were studied in phantom. Native and post-contrast T -times and regional ECV were determined in 20 healthy subjects (10 men, 27 ± 5 years). Subjective image quality, susceptibility artifact rating, in-vivo precision and reproducibility were analyzed. SR T -mapping showed <4 % deviation from the spin-echo reference in phantom in the range of T  = 100-2300 ms. The average quality and artifact scores of the T -mapping methods were: MOLLI:3.4/3.6, SAPPHIRE:3.1/3.4, SASHA:2.9/3.2; (1: poor - 4: excellent/1: strong - 4: none). SAPPHIRE and SASHA yielded significantly higher T -times (SAPPHIRE: 1578 ± 42 ms, SASHA: 1523 ± 46 ms), in-vivo T -time variation (SAPPHIRE: 60.1 ± 8.7 ms, SASHA: 70.0 ± 9.3 ms) and lower ECV-values (SAPPHIRE: 0.20 ± 0.02, SASHA: 0.21 ± 0.03) compared with MOLLI (T : 1181 ± 47 ms, ECV: 0.26 ± 0.03, Precision: 53.7 ± 8.1 ms). No significant difference was found in the inter-subject variability of T -times or ECV-values (T : p = 0.90, ECV: p = 0.78), the observer agreement (inter: p > 0.19; intra: p > 0.09) or consistency (inter: p > 0.07; intra: p > 0.17) between the three methods. Saturation-recovery T -mapping at 3T yields higher accuracy, comparable inter-subject, inter- and intra-observer variability and less than 30 % precision-loss compared to MOLLI.