Mechanism of zinc-induced phosphorylation of p70 S6 kinase and glycogen synthase kinase 3beta in SH-SY5Y neuroblastoma cells

• Published in: Journal of neurochemistry Vol. 92; no. 5; p. 1104
• Main Authors: An, Wen-Lin, Bjorkdahl, Cecilia, Liu, Rong, Cowburn, Richard F, Winblad, Bengt, Pei, Jin-Jing
• Format: Journal Article
• Language: English
• Published: England 01.03.2005
• Subjects: Analysis of Variance; Animals; Antibiotics, Antineoplastic - pharmacology; Blotting, Western - methods; Brain - drug effects; Brain - metabolism; Brain - ultrastructure; Cell Line, Tumor - drug effects; Cell Survival - drug effects; Culture Media, Serum-Free - pharmacology; Cytoplasm - drug effects; Cytoplasm - metabolism; Cytoplasm - ultrastructure; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors - pharmacology; Glycogen Synthase Kinase 3 - antagonists & inhibitors; Glycogen Synthase Kinase 3 - metabolism; Glycogen Synthase Kinase 3 beta; Humans; Immunohistochemistry - methods; In Vitro Techniques; Medicin och hälsovetenskap; Microscopy, Immunoelectron - methods; Models, Biological; Neuroblastoma; Phosphorylation - drug effects; rab5 GTP-Binding Proteins - metabolism; Rats; Ribosomal Protein S6 Kinases, 70-kDa - antagonists & inhibitors; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Sirolimus - pharmacology; tau Proteins - metabolism; Tetrazolium Salts; Thiazoles; Time Factors; Zinc - pharmacology; Zinc Sulfate - pharmacology

We have previously reported an aberrant accumulation of activated protein kinase B (PKB), glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), p38 and p70 S6 kinase (p70S6K) in neurons bearing neurofibrillary tangles (NFTs) in Alzheimer...