Lack of thyroid hormone receptor alpha1 is associated with selective alterations in behavior and hippocampal circuits

• Published in: Molecular psychiatry Vol. 8; no. 1; pp. 30 - 38
• Main Authors: Guadaño-Ferraz, A, Benavides-Piccione, R, Venero, C, Lancha, C, Vennström, B, Sandi, C, DeFelipe, J, Bernal, J
• Format: Journal Article
• Language: English
• Published: England 01.01.2003
• Subjects: Animals; Behavior, Animal - physiology; Conditioning (Psychology) - physiology; Fear - physiology; gamma-Aminobutyric Acid - physiology; Hippocampus - chemistry; Hippocampus - cytology; Hippocampus - physiology; Interneurons - chemistry; Interneurons - physiology; Male; Medicin och hälsovetenskap; Memory - physiology; Mice; Mice, Inbred BALB C; Mice, Mutant Strains; Neural Inhibition - physiology; Parvalbumins - analysis; Pyramidal Cells - chemistry; Pyramidal Cells - physiology; Thyroid Hormone Receptors alpha - analysis; Thyroid Hormone Receptors alpha - genetics; Thyroid Hormones - analysis

Brain development and function are dependent on thyroid hormone (T3), which acts through nuclear hormone receptors. T3 receptors (TRs) are transcription factors that activate or suppress target gene expression in a hormone-dependent or -independent fashion. Two distinct genes, TRalpha and TRbeta, en...