表观遗传学在瘦型非酒精性脂肪性肝病中的作用及临床应用前景

表观遗传学机制在非酒精性脂肪性肝病 (NAFLD) 的发生、发展中扮演着至关重要的角色，尤其是在瘦人群体中，相关表观遗传学机制的研究为揭示NAFLD的潜在病因和治疗策略提供了新的线索和方向。本文介绍了近年表观遗传学在瘦型NAFLD发展中的作用，分析了瘦型NAFLD表观遗传学方面的最新研究进展，简述了表观遗传学的基本概念，包括DNA甲基化、组蛋白修饰和非编码RNA调控，并探讨了表观遗传学改变如何影响瘦型NAFLD的发病机制、疾病进展以及治疗策略。...

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Published inLinchuang gandanbing zazhi Vol. 41; no. 6; p. 1161
Main Authors 徐俊姣, 刘素彤, 张琪振, 管雅捷, 崔蓓蕾, 吴文静, 刘鸣昊
Format Journal Article
LanguageChinese
Published Changchun Journal of Clinical Hepatology 01.06.2025
Online AccessGet full text
ISSN1001-5256
2097-3497
DOI10.12449/JCH250624

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Abstract 表观遗传学机制在非酒精性脂肪性肝病 (NAFLD) 的发生、发展中扮演着至关重要的角色，尤其是在瘦人群体中，相关表观遗传学机制的研究为揭示NAFLD的潜在病因和治疗策略提供了新的线索和方向。本文介绍了近年表观遗传学在瘦型NAFLD发展中的作用，分析了瘦型NAFLD表观遗传学方面的最新研究进展，简述了表观遗传学的基本概念，包括DNA甲基化、组蛋白修饰和非编码RNA调控，并探讨了表观遗传学改变如何影响瘦型NAFLD的发病机制、疾病进展以及治疗策略。
AbstractList 表观遗传学机制在非酒精性脂肪性肝病 (NAFLD) 的发生、发展中扮演着至关重要的角色，尤其是在瘦人群体中，相关表观遗传学机制的研究为揭示NAFLD的潜在病因和治疗策略提供了新的线索和方向。本文介绍了近年表观遗传学在瘦型NAFLD发展中的作用，分析了瘦型NAFLD表观遗传学方面的最新研究进展，简述了表观遗传学的基本概念，包括DNA甲基化、组蛋白修饰和非编码RNA调控，并探讨了表观遗传学改变如何影响瘦型NAFLD的发病机制、疾病进展以及治疗策略。
Author 管雅捷
崔蓓蕾
张琪振
刘鸣昊
徐俊姣
吴文静
刘素彤
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Title 表观遗传学在瘦型非酒精性脂肪性肝病中的作用及临床应用前景
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