Frontiers in New Drug Discovery From Molecular Targets to Preclinical Trials

• Format: eBook
• Language: English
• Published: Basel MDPI - Multidisciplinary Digital Publishing Institute 2023
• Subjects: A375 melanoma cells; acetylcholinesterase inhibitors; Alzheimer’s disease; anti-cancer; anti-inflammatory substance; antimicrobials; arylazo sulfones; azomethine ylide; Biology, life sciences; biomarker; butyrylcholinesterase inhibitors; cancer prognosis; cancer severity; central nervous system; cycloaddition; cytotoxic activity; cytotoxicity; deep neural network; diffuse large B cell lymphoma (DLBCL); DNA binding; DNA cleavage; DNA photocleavage; drug combination; drug discovery; epithelial regeneration; ex vivo; five-coordinate complexes; glycoconjugation; inflammation; Kunitz-type peptides; LASSBio-1524 analogues; lipophilicity; MAFB; magnetic resonance imaging; Mathematics and Science; MD simulation; metformin; minipigs; molecular docking; N-acylhydrazone; n/a; naphthyl-N-acylhydrazone; natural products; neuroprotective activity; N–S bond homolysis; P2X7R; Parkinson’s disease (PD); phosphacoumarin; photodynamic therapy; platinum(II); pravastatin; prostate cancer; protein X-ray structure; QSAR; quantum chemistry; radiation-induced intestinal injury; radicals; Reference, Information and Interdisciplinary subjects; Research and information: general; sea anemones; Streptococci; TRPV1; tumor-associated macrophages
• DOI: 10.3390/books978-3-0365-7682-4
• ISBN: 9783036576824; 3036576835; 3036576827; 9783036576831

The intention of this Special Issue is to focus on new aspects of drug discovery, including the search for new molecular targets of various diseases, the creation of new modern methods for diagnosing diseases, the development of new test systems and kits for assessing the selectivity and effectiveness of new drugs, the study of the molecular mechanisms of biologically active compounds, the formulation of new drugs, pharmacokinetic and pharmacodynamic studies, and preclinical trials of important molecules.