P-284 PGE2 Is a Robust Mediator of Chloride and Water Secretion by Human Intestinal Epithelial Cells

• Published in: Inflammatory bowel diseases Vol. 23; no. suppl_1; pp. S91 - S92
• Main Authors: Nagata, Sayaka, Fujii, Satoru, Suzuki, Kohei, Kawamoto, Ami, Ishibashi, Fumiaki, Nakata, Toru, Anzai, Sho, Kuno-Ishii, Reiko, Ito, Go, Shimizu, Hiromichi, Tsuchiya, Kiichiro, Nakamura, Tetsuya, Ootsuka, Kazuo, Okamoto, Ryuichi, Watanabe, Mamoru
• Format: Journal Article
• Language: English
• Published: Oxford, UK Oxford University Press 01.02.2017
• Subjects: Algorithms; Aquaporins; Bone marrow; Cells; Colon; Infections; Inflammation; Inflammatory bowel disease; Pathogens; Signal transduction; Small intestine; Tumorigenesis

Human intestinal epithelial cells (IECs) play an indispensable role in maintaining proper body fluid balance, partly through their ability to secrete chloride ion. However, in various inflammatory bowel diseases (IBDs), over-secretion of the Cl− is induced in IECs, leading to symptoms such as severe...