Structure of the nucleation‐promoting factor SPIN90 bound to the actin filament nucleator Arp2/3 complex

• Published in: The EMBO journal Vol. 37; no. 22
• Main Authors: Luan, Qing, Liu, Su‐Ling, Helgeson, Luke A, Nolen, Brad J
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 15.11.2018; Springer Nature B.V; John Wiley and Sons Inc
• Subjects: Actin; Arp2/3 complex; Assembly; Binding sites; Crystal structure; EMBO05; EMBO40; Filaments; Nucleation; Protein structure; Proteins; SPIN90; WASP; Arp2/3 complex; nucleation; actin; SPIN90; WASP

Unlike the WASP family of Arp2/3 complex activators, WISH/DIP/SPIN90 (WDS) family proteins activate actin filament nucleation by the Arp2/3 complex without the need for a preformed actin filament. This allows WDS proteins to initiate branched actin network assembly by providing seed filaments that a...